Henry William de Saussure (August 16, 1763 – March 26, 1839) was an American lawyer, state legislator and jurist from South Carolina who became a political leader as a member of the Federalist Party following the Revolutionary War. He was appointed by President George Washington as the 2nd Director of the United States Mint, was a co-sponsor of the legislation that established the South Carolina College which was to become the University of South Carolina and was given the title of Chancellor as a justice of the SC Equity Court, also known as chancery court. In this capacity he wrote and codified much of the state's equity law still in use today. He served as Intendant (Mayor) of both Charleston and Columbia, SC.