A busy stand-up comedian, Guzmán's best known role to date is as the voice of El Chavo (and his friend Godínez) in the animated El Chavo series (based on TV characters created in the 1970s by comedian Roberto Gómez Bolaños, aka Chespirito). Guzmán has also voiced the animated version of Chespirito's other best known character, El Chapulin Colorado, first in guest appearances or promos and then in a 2015 series. He dubbed Hector David, Jr. on Power Rangers Samurai, Michael Rooker in Guardians of the Galaxy, Terry Perry in Monsters University, Rhino in Bolt, and Bing Bong in Inside Out. He filmed an on-camera, English speaking role in the upcoming film Mind Puppets.