Gaturro is a cat and the protagonist of the comic. He lives with his owners who have raised him since he was young. While his house is a charming place, he also enjoys roaming the rooftops of his neighborhood. Among the rooftops, Gaturro can interact with other characters from neighboring houses. Gaturro's owners send him to school every now and then, not for the education, but to get him out of the house. In school, Gaturro is a bit of a troublemaker and makes life difficult for his teacher, Ms. Ruda Vinagreti. Gaturro has also appeared dressed in formal clothes at his owner's office in some strips to issue a punchline in the form of a thought bubble, but what he does there has not really been explained.