"They" are apparently malevolent extradimensional entities, though whether this refers to a specific alien race or a broad class of hostile races is unknown. What we can surmise about "Them" is mostly taken from the mad rantings of Science Officer Bukowski during an exploration of the ruins on the Androsynth homeworld. Bukowski, having reconstructed the computer records at various Androsynth research stations, learned about the Androsynth efforts in Inter-Dimensional Fatigue and their contact with an alien life-form from another dimension. After ten hours of examining the intact computer records in the third set of ruins, he became noticeably agitated. Bukowski then proceeded to destroy the computer records out of fear of "Them".