The skit starred SNL host Conan O'Brien as a superhero named Moleculo: The Molecular Man, a parody of Superman. On hearing his name, "Moleculo", whether in costume or not, would turn to the camera and shout "THE MOLECULAR MAN!" The sketch begins with the Moleculo theme song, a parody of typical superhero fare, showcasing Moleculo's bravery and great strength (he bends a bar of iron) to the tune "Moleculo, Moleculo, MOLECULO", to which Moleculo says "The Molecular Man."