Norman Osborn first appears as the owner of Oscorp and the father of Harry Osborn. He is initially pleasent and supporting of Peter's friendship and also scientific potential, also wanting his own son to recognize his own potential. Unfortunately, his company begins to struggle, with Osborn's promised performance-enhancing serum having been hit with setbacks, not the least of which being that rodents it was tested on displayed violence, aggression, and insanity. Upon being told that his funding is on the verge of being cut, Norman becomes desperate and ultimately tests the serum on himself. The process drives him mad and he promptly murders his own scientist Doctor Stromm. He wakes up afterwards in his home amnesiac and sick.