The Father, the Son and the Holy Guest Star is the twenty first and final episode of Season 16. The episode is the 350th episode produce (in production order) of The Simpsons. Originally slated to air April 10, 2005, it was postponed with no episode playing that night (it was finally aired May 15, 2005) due to the death earlier that week of Pope John Paul II, as the episode revolved around the Roman Catholic Church.