The Siege of Niezijl was a siege of the town of Niezijl that took place between 3 and 24 October 1581 in the Dutch States, during the Eighty Years' War and the Anglo-Spanish War (1585–1604). The Spanish under Colonel Francisco Verdugo laid siege to the place after his victory at the battle of Noordhorn but the siege failed and Verdrugo retreated leaving the English and Dutch under John Norreys and William Louis respectively the victors.