Meche was a member of the U.S. Junior Olympic team in 1995. During his senior season at Acadiana High school, Meche suffered from a viral infection that caused him to miss a considerable amount of time playing baseball. Because of his tremendous potential, Meche was still chosen in the 1st round of the 1996 amateur draft. His first Major League game was on July 6, 1999, against the Anaheim Angels, making him the second youngest debut for the Mariners at that time. He made his return in to professional baseball on April 5, 2003.