USS S-41 (SS-146), a, was a first-group (S-1 or "Holland") S-class submarine of the United States Navy. Her keel was laid down on 17 April 1919 by the Bethlehem Shipbuilding Corporation in San Francisco, California. She was launched on 21 February 1921 sponsored by Mrs. John F. Conners, and commissioned on 15 January 1924 with Lieutenant A. H. Donahue in command.