The show follows the daily exploits of a lazy, young panda, named Panda. Constantly told by his mother to get a job, he one day stumbles into the titular cafe, run by the enigmatic Shirokuma, a soft spoken polar bear. Joining them, are Shirokuma's friend, a sarcastic penguin named Penguin, various animals from the nearby zoo, and Shirokuma's sole employee, a human girl named Sasako.