Simon, Lloyd Simcoe, and their compatriots were working on a project that was then used by someone else to cause the Blackout. This would seem to explain why one the people we know were "responsible" had a flashforward. Perhaps they're not responsible in the literal sense, but they feel so because it was their research that led to the event. * Lloyd felt responsible since their experiment coincided with the blackout. * It was said in "Revelation Zero, Part 2" that their experiment did indeed amplify the effects, but wasn't the primary cause of the GBO.