The Binding of Isaac is a hybrid Roguelike/shooter made by Edmund McMillen, a co-creator of Meat Boy, and Florian Himsl, released in September 2011. The story follows Isaac, a young boy who is in possibly the worst situation imaginable. After his mother heard commands from God that she followed without question, she is commanded to kill her son in sacrifice to prove her devotion. Isaac manages to escape into the basement, and is on the run as he fights off demons both physical and mental, discovers secrets about his mother's past, and ultimately confronts her in an effort to survive.
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