Tlepolemus (in Greek Tληπoλεμoς; lived 4th century BC) was the son of Pythophanes and one of the hetairoi of Alexander the Great, who was joined in the government of the Parthians and Hyrcanii with Amminapes, a Parthian, whom Alexander had appointed satrap of those provinces. At a later period Tlepolemus was appointed by Alexander satrap of Carmania, which he retained on the death of Alexander in 323 BC, and also at the fresh division of the provinces at Triparadisus in 321 BC.