Santa Modesta was a fictional small town in southern California. It was the setting of several levels in Destroy All Humans!. Crypto first arrives here after he learns of the town's existence in Rockwell. During his first visit to the town, Crypto infiltrates the Mayor of Santa Modesta's pool party, kills the Mayor and most of the other guests, and ultimately obliterates the bulk of the Santa Modesta Police. On his final mission in the region, Crypto tests out his newly Quantum Deconstructor on the city. Crypto was never required to return to the town.