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Electron Density Puzzles

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Electron Density Puzzles consist of an unsolved protein and an electron density "cloud". The electron density cloud represents where the electrons of the protein's amino acids are likely to be found. The cloud is usually determined experimentally, and provides an insight into what the native structure of the protein will look like, once solved. Electron density puzzles have a density component to the segment score. The more completely a segment is covered by the density cloud, the higher the score.

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Electron Density Puzzles consist of an unsolved protein and an electron density "cloud". The electron density cloud represents where the electrons of the protein's amino acids are likely to be found. The cloud is usually determined experimentally, and provides an insight into what the native structure of the protein will look like, once solved. Electron density puzzles have a density component to the segment score. The more completely a segment is covered by the density cloud, the higher the score. The objective of Electron Density puzzles is to fit the protein neatly into the electron density cloud, so that little or no part of the protein structure sticks out of the cloud, at a medium density threshold. A segment may have a positive density score even when it lies outside the visible density cloud. Beyond the visible portion of the density, the same cloud repeats invisibly. Segments may end up aligned with in this invisible density cloud. In some puzzles, such as 1152: Foldit vs. UMich Electron Density Challenge, the entire protein may not fit within the visible portion of the electron density cloud.