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Subject Item
n2:
rdfs:label
Mefenamic acid
rdfs:comment
Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis.
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dbr:Mefenamic_acid
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n24:
2005-09-28
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90.0
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263877360
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肝臟 Hepatic
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Renal and fecal n35:
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M01
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℞-only , POM in UK
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1
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241.285
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90.0
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en
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2
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4044
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C
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AG01
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2 7200.0
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http://archinte.ama-assn.org/cgi/content/abstract/160/6/777|title=Consumption of NSAIDs and the Development of Congestive Heart Failure in Elderly Patients http://cardiology.jwatch.org/cgi/content/full/2002/315/3|title=NSAIDs May Increase Risk for Worsening Heart Failure http://www.rxlist.com/cgi/generic3/mefenamic_cp.htm|title=Ponstel Pharmacology, Pharmacokinetics, Studies, Metabolism - Mefenamic Acid - RxList Monographs http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a681028.html|title=MedlinePlus Drug Information: Mefenamic Acid
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changed
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APRD0073
n44:
口服 Oral
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2
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n13:abstract
Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis. Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.