"\uC9C0\uBC29\uC0B0 \uB300\uC0AC"@ko . . "\uC9C0\uBC29\uC0B0 \uB300\uC0AC\uC640 \uD0C4\uC218\uD654\uBB3C \uB300\uC0AC\uB294 \uC0C1\uD638\uAD00\uB828\uC774 \uC788\uB2E4. \uD638\uB974\uBAAC\uC778 \uAE00\uB8E8\uCE74\uACE4\uACFC \uC5D0\uD53C\uB124\uD504\uB9B0 \uADF8\uB9AC\uACE0 \uAE30\uC9C8\uC778 \uC2DC\uD2B8\uB974\uC0B0, \uB9D0\uB860\uC77C-CoA \uBC0F \uD314\uBBF8\uD1A0\uC77C-CoA\uB294 \uC9C0\uBC29\uC0B0 \uB300\uC0AC\uC758 \uC911\uC694\uD55C \uC870\uC808\uC790\uC774\uB2E4. \uD638\uB974\uBAAC\uC758 \uC77C\uC885\uC778 \uB819\uD2F4(leptin)\uC774 \uADFC\uC721\uC5D0 \uC874\uC7AC\uD558\uB294 \uC9C0\uBC29\uC0B0(fatty acids)\uC744 \uB300\uC0AC\uC2DC\uD0A4\uB294 \uAE30\uC791\uC744 \uBD84\uC790 \uC218\uC900\uC5D0\uC11C \uADDC\uBA85\uD55C \uC0C8\uB85C\uC6B4 \uC5F0\uAD6C \uACB0\uACFC\uAC00 \uBC1C\uD45C\uB410\uB2E4. \uC774\uBC88 \uC5F0\uAD6C \uC131\uACFC\uB294 \uB2F9\uB1E8\uBCD1(diabetes)\uACFC \uBE44\uB9CC(obesity) \uC0AC\uC774\uC758 \uAD00\uACC4\uB97C \uBD84\uC790 \uC218\uC900\uC5D0\uC11C \uADDC\uBA85\uD55C \uCD5C\uCD08\uC758 \uC5F0\uAD6C \uC0AC\uB840\uB85C \uBE44\uB9CC\uACFC \uB2F9\uB1E8\uBCD1 \uCE58\uB8CC\uC5D0 \uC720\uC6A9\uD55C \uC0C8\uB85C\uC6B4 \uC57D\uBB3C \uD45C\uC801\uC744 \uB3D9\uC815\uD558\uB294\uB370 \uD070 \uB3C4\uC6C0\uC744 \uC904 \uAC83\uC73C\uB85C \uC804\uB9DD\uB41C\uB2E4. \uBBF8\uAD6D BIDMC(Beth Israel Deaconess Medical Center)\uC758 \uACFC\uD559\uC790\uB4E4\uC774 \uC218\uD589\uD55C \uC774\uBC88 \uC5F0\uAD6C\uC758 \uACB0\uACFC\uB294 \uC601\uAD6D\uC758 \uC800\uBA85\uD55C \uD559\uC220\uC9C0 \"\uB124\uC774\uCCD0(Nature)\", 1\uC6D4 17\uC77C\uC790\uC5D0 \uC18C\uAC1C\uB410\uB2E4. \uBD84\uB958:\uBB3C\uC9C8 \uB300\uC0AC"@ko . . "\uC9C0\uBC29\uC0B0 \uB300\uC0AC\uC640 \uD0C4\uC218\uD654\uBB3C \uB300\uC0AC\uB294 \uC0C1\uD638\uAD00\uB828\uC774 \uC788\uB2E4. \uD638\uB974\uBAAC\uC778 \uAE00\uB8E8\uCE74\uACE4\uACFC \uC5D0\uD53C\uB124\uD504\uB9B0 \uADF8\uB9AC\uACE0 \uAE30\uC9C8\uC778 \uC2DC\uD2B8\uB974\uC0B0, \uB9D0\uB860\uC77C-CoA \uBC0F \uD314\uBBF8\uD1A0\uC77C-CoA\uB294 \uC9C0\uBC29\uC0B0 \uB300\uC0AC\uC758 \uC911\uC694\uD55C \uC870\uC808\uC790\uC774\uB2E4. \uD638\uB974\uBAAC\uC758 \uC77C\uC885\uC778 \uB819\uD2F4(leptin)\uC774 \uADFC\uC721\uC5D0 \uC874\uC7AC\uD558\uB294 \uC9C0\uBC29\uC0B0(fatty acids)\uC744 \uB300\uC0AC\uC2DC\uD0A4\uB294 \uAE30\uC791\uC744 \uBD84\uC790 \uC218\uC900\uC5D0\uC11C \uADDC\uBA85\uD55C \uC0C8\uB85C\uC6B4 \uC5F0\uAD6C \uACB0\uACFC\uAC00 \uBC1C\uD45C\uB410\uB2E4. \uC774\uBC88 \uC5F0\uAD6C \uC131\uACFC\uB294 \uB2F9\uB1E8\uBCD1(diabetes)\uACFC \uBE44\uB9CC(obesity) \uC0AC\uC774\uC758 \uAD00\uACC4\uB97C \uBD84\uC790 \uC218\uC900\uC5D0\uC11C \uADDC\uBA85\uD55C \uCD5C\uCD08\uC758 \uC5F0\uAD6C \uC0AC\uB840\uB85C \uBE44\uB9CC\uACFC \uB2F9\uB1E8\uBCD1 \uCE58\uB8CC\uC5D0 \uC720\uC6A9\uD55C \uC0C8\uB85C\uC6B4 \uC57D\uBB3C \uD45C\uC801\uC744 \uB3D9\uC815\uD558\uB294\uB370 \uD070 \uB3C4\uC6C0\uC744 \uC904 \uAC83\uC73C\uB85C \uC804\uB9DD\uB41C\uB2E4. \uBBF8\uAD6D BIDMC(Beth Israel Deaconess Medical Center)\uC758 \uACFC\uD559\uC790\uB4E4\uC774 \uC218\uD589\uD55C \uC774\uBC88 \uC5F0\uAD6C\uC758 \uACB0\uACFC\uB294 \uC601\uAD6D\uC758 \uC800\uBA85\uD55C \uD559\uC220\uC9C0 \"\uB124\uC774\uCCD0(Nature)\", 1\uC6D4 17\uC77C\uC790\uC5D0 \uC18C\uAC1C\uB410\uB2E4. \uB819\uD2F4\uC740 \uC9C0\uB09C 1994\uB144\uC5D0 \uCC98\uC74C\uC73C\uB85C \uB3D9\uC815\uB41C \uD638\uB974\uBAAC\uC73C\uB85C \uC2DD\uC695\uC744 \uC5B5\uC81C\uD558\uB294 \uC778\uC790\uB85C \uC791\uC6A9\uD55C\uB2E4. \uB819\uD2F4\uC5D0 \uB300\uD55C \uC120\uD589 \uC5F0\uAD6C \uACB0\uACFC\uB4E4\uC5D0 \uB530\uB974\uBA74, \uC774 \uD638\uB974\uBAAC\uC740 \uC9C0\uBC29 \uC138\uD3EC\uC5D0\uC11C \uC0DD\uC131\uB418\uBA70 \uD608\uB958\uB97C \uB530\uB77C \uC774\uB3D9\uD574 \uB1CC\uC5D0 \uC874\uC7AC\uD558\uB294 \uC218\uC6A9\uCCB4(receptors)\uC640 \uC0C1\uD638 \uC791\uC6A9\uC744 \uB098\uD0C0\uB0C4\uC73C\uB85C\uC368 \uC74C\uC2DD\uBB3C \uC12D\uCDE8\uB97C \uC911\uB2E8\uC2DC\uD0A4\uB294 \uC2E0\uD638\uB97C \uC804\uB2EC\uD55C\uB2E4. \uC774\uD6C4 \uC218\uD589\uB41C \uB610 \uB2E4\uB978 \uC5F0\uAD6C\uB97C \uD1B5\uD574 \uB819\uD2F4\uC774 \uBA74\uC5ED\uACC4(immune system)\uB97C \uAD6C\uC131\uD558\uB294 T \uC138\uD3EC\uC640 \uC2E0\uC0DD \uD608\uAD00\uC5D0\uB3C4 \uC874\uC7AC\uD55C\uB2E4\uB294 \uC0AC\uC2E4\uC774 \uBC1D\uD600\uC9C0\uBA74\uC11C \uC2E0\uC9C4\uB300\uC0AC \uACFC\uC815\uC5D0\uC11C\uB3C4 \uC774 \uD638\uB974\uBAAC\uC774 \uC911\uC694\uD55C \uC5ED\uD560\uC744 \uB2F4\uB2F9\uD55C\uB2E4\uB294 \uAC00\uC124\uC774 \uC81C\uAE30\uB418\uAE30\uC5D0 \uC774\uB978\uB2E4. \uB819\uD2F4\uC774 \uB300\uC0AC \uACFC\uC815\uC5D0\uC11C \uC77C\uC885\uC758 \uC870\uC808\uC790(regulator)\uB85C \uC791\uC6A9\uD560 \uC218 \uC788\uB2E4\uB294 \uAC83\uC774\uB2E4. \uBE44\uB9CC\uACFC 2\uD615 \uB2F9\uB1E8\uBCD1\uC740 \uC5D0\uB108\uC9C0 \uB300\uC0AC \uACFC\uC815\uC5D0 \uBB38\uC81C\uB97C \uB3D9\uBC18\uD55C\uB2E4\uB294 \uACF5\uD1B5\uC810\uC744 \uAC16\uB294\uB2E4. \uADFC\uC721\uACFC \uAC04\uC758 \uC9C0\uBC29\uC0B0\uC774 \uCDA9\uBD84\uD788 \uC774\uC6A9\uB418\uC9C0 \uBABB\uD558\uBA74 \uC774\uB4E4\uC774 \uC18C\uBE44\uB418\uC9C0 \uBABB\uD558\uACE0 \uCD95\uC801\uB418\uBA74\uC11C \uCE7C\uB85C\uB9AC\uB97C \uC18C\uBE44\uD558\uB294 \uB300\uC0AC \uAE30\uB2A5\uC5D0 \uC774\uC0C1\uC774 \uBC1C\uC0DD\uD55C\uB2E4. \uC774 \uAC19\uC740 \uC0C1\uD0DC\uC5D0 \uC774\uB974\uBA74 \uBE44\uB9CC\uC774 \uC720\uB3C4\uB420 \uBFD0 \uC544\uB2C8\uB77C \uC778\uC290\uB9B0 \uC800\uD56D\uC131(insulin resistance)\uC774 \uC0DD\uAE30\uBA74\uC11C \uB2F9\uB1E8\uBCD1\uC774 \uBC1C\uB2EC\uD560 \uC704\uD5D8\uC774 \uD568\uAED8 \uC99D\uAC00\uD558\uB294 \uACB0\uACFC\uB97C \uBE5A\uB294\uB2E4. \uC774\uBC88 \uC5F0\uAD6C\uAC00 \uADDC\uBA85\uD55C \uB0B4\uC6A9\uC740 AMPK(5'-AMP activated protein kinase)\uB77C\uB294 \uD6A8\uC18C\uAC00 \uB819\uD2F4\uC5D0 \uB300\uD55C \uC2E0\uD638 \uC804\uB2EC \uACBD\uB85C(signaling pathway)\uB85C \uC791\uC6A9\uD568\uC73C\uB85C\uC368 \uB819\uD2F4\uC774 \uADFC\uC721\uC5D0 \uC874\uC7AC\uD558\uB294 \uC9C0\uBC29\uC0B0\uC744 \uB300\uC0AC\uC2DC\uD0A4\uB294\uB370 \uC601\uD5A5\uC744 \uBBF8\uCE5C\uB2E4\uB294 \uAC83\uC774\uB2E4. AMPK\uB294 \uC120\uD589 \uC5F0\uAD6C\uB4E4\uC744 \uD1B5\uD574 \uCF5C\uB808\uC2A4\uD14C\uB864 \uB300\uC0AC\uC640 \uAE00\uB9AC\uCF54\uAC90 \uD569\uC131 \uACFC\uC815\uC5D0\uC11C \uD575\uC2EC \uC778\uC790\uB85C \uC791\uC6A9\uD558\uB294 \uD6A8\uC18C\uB85C \uB3D9\uC815\uB41C \uBB3C\uC9C8\uC774\uAE30\uB3C4 \uD558\uB2E4. \uC2E4\uD5D8\uC744 \uD1B5\uD574 \uD655\uC778\uB41C \uB819\uD2F4\uC758 \uAE30\uB2A5\uC740 AMPK\uC758 \uD65C\uC131\uC744 \uC9C1\uC811\uC801\uC73C\uB85C \uC720\uB3C4\uD55C\uB2E4\uB294 \uAC83\uC774\uB2E4. \uC774\uC678\uC5D0 \uC774\uBC88 \uC5F0\uAD6C\uB294 \uB819\uD2F4\uC774 AMPK\uC5D0 \uC601\uD5A5\uC744 \uBBF8\uCE58\uB294 \uBC29\uC2DD\uC73C\uB85C ACC(acetylCoA carboxylase) \uAC19\uC740 \uB610 \uB2E4\uB978 \uD6A8\uC18C\uB97C \uC800\uD574\uD560 \uC218 \uC788\uB2E4\uB294 \uC0AC\uC2E4\uB3C4 \uD655\uC778\uD588\uB2E4. ACC\uB294 \uC9C0\uBC29 \uB300\uC0AC\uAC00 \uC99D\uAC00\uD560 \uACBD\uC6B0\uC5D0 \uC0DD\uC131\uB418\uB294 \uD6A8\uC18C \uBB3C\uC9C8 \uAC00\uC6B4\uB370 \uD558\uB098\uC774\uB2E4. \uC774 \uAC19\uC740 \uC77C\uB828\uC758 \uC5F0\uAD6C \uACB0\uACFC\uB4E4\uC740 AMPK \uB300\uC0AC \uACBD\uB85C\uAC00 \uBE44\uB9CC\uACFC \uB2F9\uB1E8\uBCD1\uC744 \uCE58\uB8CC\uD558\uB294\uB370 \uC720\uC6A9\uD55C \uC57D\uBB3C \uD45C\uC801\uC744 \uB3D9\uC815\uD558\uB294\uB370 \uC751\uC6A9\uB420 \uC218 \uC788\uC74C\uC744 \uC758\uBBF8\uD55C\uB2E4. \uC5F0\uAD6C\uC9C4\uC5D0 \uB530\uB974\uBA74, AMPK\uB294 \uC774\uC9C8\uC131 \uC0BC\uB2E8\uC704\uCCB4 \uD6A8\uC18C(heterotrimeric enzyme)\uC5D0 \uC18D\uD55C\uB2E4. AMPK\uAC00 \uC774\uC9C8\uC131 \uC0BC\uB2E8\uC704\uCCB4 \uD6A8\uC18C\uB77C\uB294 \uAC83\uC740 \uC774 \uD6A8\uC18C\uAC00 \uC54C\uD30C, \uBCA0\uD0C0, \uAC10\uB9C8\uC758 \uC138 \uBD80\uBD84\uC73C\uB85C \uAD6C\uBD84\uB418\uBA70 \uAC01 \uBD80\uBD84\uC5D0 \uB450 \uAC1C\uC5D0\uC11C \uC138 \uAC1C\uC758 \uC774\uC131\uCCB4(isoforms) \uB4E4\uC774 \uD3EC\uD568\uB418\uC5B4 \uC788\uC74C\uC744 \uC758\uBBF8\uD55C\uB2E4. \uC774\uBC88 \uC5F0\uAD6C\uB294 \uB819\uD2F4\uC774 \uADFC\uC721\uC758 \uC9C0\uBC29\uC0B0 \uC0B0\uD654\uC5D0 \uBBF8\uCE58\uB294 \uC601\uD5A5\uC758 \uD575\uC2EC\uC774 \uC54C\uD30C\uC5D0 \uC874\uC7AC\uD558\uB294 \uB2E8\uC77C \uC774\uC131\uCCB4\uC5D0 \uC788\uB2E4\uB294 \uC0AC\uC2E4\uC744 \uD655\uC778\uD588\uB2E4. \uC774 \uAC19\uC740 AMPK \uD6A8\uC18C\uC758 \uD2B9\uC131\uC740 \uB9E4\uC6B0 \uC911\uC694\uD55C \uC758\uBBF8\uB97C \uAC16\uB294\uB2E4\uACE0 \uD55C\uB2E4. \uC65C\uB0D0\uD558\uBA74 AMPK\uAC00 \uC774\uC9C8\uC131 \uC0BC\uB2E8\uC704\uCCB4 \uD6A8\uC18C\uB77C\uB294 \uAC83\uC740 \uC774 \uBB3C\uC9C8\uC758 \uBD84\uC790 \uD2B9\uC774\uC131(molecular specificity)\uC774 \uB192\uB2E4\uB294 \uAC83\uC744 \uAC00\uB9AC\uD0A4\uACE0 \uC774\uB294 \uD2B9\uC774\uC131\uC774 \uB192\uC740 \uC57D\uBB3C \uAC1C\uBC1C\uC774 \uAC00\uB2A5\uD568\uC744 \uC758\uBBF8\uD558\uAE30 \uB54C\uBB38\uC774\uB2E4. \uC57D\uBB3C\uC758 \uD2B9\uC774\uC131\uC774 \uB192\uC744 \uACBD\uC6B0\uC5D0\uB294 \uB3D9\uBC18\uD558\uB294 \uBD80\uC791\uC6A9\uC744 \uD06C\uAC8C \uC904\uC774\uB294 \uC7A5\uC810\uC744 \uD655\uBCF4\uD560 \uC218 \uC788\uB2E4. \uBD84\uB958:\uBB3C\uC9C8 \uB300\uC0AC"@ko .