. . "I'm not even sure that DNA replication would be possible. 5' to 3' is such an essential part of replication that without it, polymerase would just cut randomly i think. Also, all of the other enzymes would be completly lost and would likely be rendered useless. Fortunatly, I don't think that this is likely to happen!"@en . "I'm not even sure that DNA replication would be possible. 5' to 3' is such an essential part of replication that without it, polymerase would just cut randomly i think. Also, all of the other enzymes would be completly lost and would likely be rendered useless. Fortunatly, I don't think that this is likely to happen!"@en . "What would the consequences to replication be if DNA polymerase I lost its 5\u2019 to 3\u2019 exonuclease activity"@en .