"Assuming you mean in a manner other than just shooting someone in the face, you need the Mister Sandman perk. Then, while any human or ghoul is sleeping, crouch and sneak up on them as though pickpocketing. When in reach of your victim you will get the option to pickpocket or murder them, choose murder, then enjoy the happy tune and and throat-slitting animation."@en . "How do you murder fallout3"@en . . "Assuming you mean in a manner other than just shooting someone in the face, you need the Mister Sandman perk. Then, while any human or ghoul is sleeping, crouch and sneak up on them as though pickpocketing. When in reach of your victim you will get the option to pickpocket or murder them, choose murder, then enjoy the happy tune and and throat-slitting animation."@en . . .